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A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR

In a study using A53T mice, a high-calorie diet exacerbated autonomic dysfunction that occurs in early disease stages in these animals

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4,5,6 The term pernicious anaemia refers to an autoimmune disease that destroys the parietal cells, leading to a lack of IF and thus B12 deficiency

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