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However, CPG20712A may cross the bloodbrain barrier ( 1 AR and 2 AR ( 2 AR-mediated stimulation of norepinephrine release

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The levels of several enzymes controlling de novo serine synthesis such as phosphoserine phosphatase (PSPH), phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1) and have been identified differentially elevated in breast cancer cells with high propensity for bone metastasis as compared with those without metastatic potency [87], implicating the stimulatory role of serine on osteoclast formation and osteoclastogenesis [87, 88]