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Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer

Just be aware that there is high altitude (in Puno and Cusco) and some walking involved

In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotrienol

Inflammation 36:13631373

J Neurol Disord 1:107 Duda CD (2012) Dietary and Biochemical Markers of Folate in the Consideration of Depression