glutathione peroxidase deficiency anemia Rasburicase-Induced Hemolytic Secondary to Undiagnosed G6PD Role of G6PD in managing

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While UK healthcare professionals can, in exceptional circumstances, prescribe unlicensed medicines under the MHRA 'specials' framework, this would rarely be appropriate for ED given the availability of licensed, evidence-based alternatives

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As early as a few decades ago, it was shown that the glycocalyx covers the surface of most vascular lumens and that microcirculatory dysfunction and endothelial damage play important roles in the multiorgan failure associated with sepsis (53), and also that endothelial dysfunction and microcirculatory impairment are determinants of the severity and duration of sepsis (54)