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Mitochondria and synaptic plasticity in the mature and aging nervous system

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These results combined with the normal initial respiratory burst in the first few minutes following PMA stimulation in Gsr / neutrophils (33, 34) strongly suggest that NADPH oxidase assembly, at least in the early phase, is not affected by Gsr deficiency

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PMID: 8001743

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Future studies should prioritize (1) isolating and characterizing the active compounds within these botanicals, (2) elucidating their precise molecular targets (e.g., thyroid peroxidase, sodium-iodide symporter, cytokine signaling pathways), and (3) conducting well-designed controlled clinical trials to rigorously evaluate their safety and efficacy in human patients

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