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Unveiling the therapeutic potential of targeting RRM2 in hepatocellular carcinoma: an integrated in silico and in vitro study

The Hyg5 cassette and GA module were amplified by PCR using pTrcBhyg5 and pT3hb6h as the templates, respectively, with the primer pair ptrc_psak_f and ptrc_psak_r

While eating fruit provides some glutathione and essential precursors like Vitamin C, the overall impact may be limited by low bioavailability

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

It is estimated by the National Cancer Institute that approximately 1020% of all cancer patients will receive a platinum drug during the course of their therapy ( The main cytotoxic mechanism of platinum is due to the generation of mono adducts and crosslinks in DNA, although other cytotoxic activities have been reported [2] (Fig