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The transcription factor hypoxia-inducible factor-1 (HIF-1) plays an important role under conditions of both hypoxia and normoxia
T., Yan, Y., Sitaraman, S
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However, some opioid agonists such as herkinorin can promote a long lasting anti-nociception without internalization due to the absence of arrestin 3 recruitment (Lamb et al., 2012)
