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In the setting of HF, SS-31 restricts cardiac hypertrophy, reduces fibrosis, improves cardiac function in mice subjected to TAC 108 , and, importantly, profoundly reduces the degree of mitochondrial ultrastructural and proteomic changes that occur 108

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Since CagriSema already contains semaglutide 2.4 mg, transitioning from standalone semaglutide to CagriSema would theoretically be simpler, though clinical guidance on this transition is limited

Whether supplementation of GlyNAC improves cardiometabolic health, for example in older adults with pronounced insulin resistance or high inflammation status remains to be studied