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and cognitive impairment [163,164]

(PubMed) Liang WC, Ohkuma A, Hayashi YK, et al

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Finally, supplementing NaGYY, the sodium salt of GYY4137, a slow-releasing H 2 S donor, restored sulfhydration and ameliorated motor and cognitive deficits in the 3xTg-AD mice (Giovinazzo et al., Figure 2 Therapeutic Avenues Analysis of clinical trials conducted so far, reveal a preference for non-amyloid targets, which include therapeutics targeting inflammation, synapse and neuronal protection, vascular factors, neurogenesis, and epigenetic modifications (Cummings et al., 2 S regulates a wide array of neuroprotective processes, therapies, and interventions involving either the use of H 2 S delivering drugs or agents which stimulate its production are gaining importance