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18 Methionine can also be recovered from methylthioadenosine (MTA), a by-product of polyamine (PA) biosynthesis, via the methionine salvage pathway

In animal studies, a disturbance in the metabolism of either of the two methyl-donor pathways, due to limited availability of either betaine or folates and vitamin B 12 , affects levels of nutrients in the coexisting pathway, because more of a drain is placed on the other pathway as a source of methyl groups

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This conversion is a crucial step in the demethylation process [55]

Int J Mol Sci 19(7):1987