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[DOI] [PubMed] [Google Scholar] 110.Raza M, Alghasham AA, Alorainy MS, El-Hadiyah TM

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For example, in breast cancer, autocrine expression of GH from the tumor cells promotes a more aggressive cellular phenotype, compared to exogenously added GH, which mimics endocrine secretion

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Hence, changes in intra-portal insulin levels need to be taken into consideration to correctly interpret the alterations in the GH/IGF-I axis in healthy and disease states as this helps the clinician in formulating the decision-making process of when and how to perform appropriate diagnostic work-up and whether to offer treatment to improve any accompanying metabolic consequences