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Why It Stands Out

Additionally, cell signaling pathways contribute to NRF2 regulation, highlighting the complex regulatory network underlying NRF2 activity

Silencing of circ-016901 increased the proliferation of BM-MSCs and ameliorated apoptosis induced by irradiation through the miR-1249-5p/HIPK2 axis [158]

Arenobufagin modulates the p62-KEAP1-NRF2 axis to trigger autophagy-dependent ferroptosis, reducing NRF2 levels and promoting tumor suppression in xenograft models [46]

However, as the up-regulation of endogenous antioxidant systems are brought about by exercise training, athletes may benefit from increasing these systems through dietary thiol donors