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This may explain why so many people say they feel amazing when taking vitamin B12 shots and injections even if they were taking oral forms of vitamin B12 previously
doi:10.1371/journal.pone.0033944 Lederman RJ, Mendelsohn FO, Anderson RD, Saucedo JF, Tenaglia AN, Hermiller JB, Hillegass WB, Rocha-Singh K, Moon TE, Whitehouse MJ et al (2002) Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial
Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D

It works quickly because healthcare providers inject the vitamin directly into the muscles, unlike supplements that may take longer to be absorbed by the body

That's a rule payers enforce through NCCI edits
