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doi: 10.1371/journal.pone.0280915, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 66.Rogal SS, Beste LA, Youk A, Fine MJ, Ketterer B, Zhang H, et al

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Senescence is triggered by various intrinsic and extrinsic factors, including DNA damage, telomere attrition, oncogene activation, and oxidative stress, as illustrated in Figure 1