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The cycling rationale relates to receptor sensitivity research: continuous GHSR stimulation may produce receptor desensitization over extended periods in some research models

[DOI] [PubMed] [Google Scholar] Markaverich B

The NADPH oxidase isoform NOX4, located in the inner mitochondrial membrane, induced the production of ROS, which inhibited p300/CBP-associated factor-dependent acetylation and lysosomal degradation of PKM2

doi: 10.18632/oncotarget.17531

Free Radical Biol.Med
