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Notably, glutathione-S-transferase (GST) does not appear to be considerably increased due to maternal cigarette smoking [101,102,103,121,122], whereas UDP-glucuronosyltransferase (UGT) activity is stimulated by both cigarette smoking and alcohol intake [124,125]

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6 Challenges and future perceptions 6.1 Current research limitations The inherent complexity of epigenetic regulation represents the primary barrier to translating findings into crop breeding applications