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In summary, establishing exercise as a redox-targeted therapy necessitates bridging the evidence gap between biomarkers and clinical endpoints while addressing the complexities of personalized prescribing and safe delivery

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Porcher, C., Liao, E

(6) Complex I: Complex I (NADH:ubiquinone oxidoreductase) is a large multiprotein complex located in the mitochondrial inner membrane that accepts electrons from NADH and transfers them to ubiquinone (CoQ 10 ) via FMN and a series of ironsulfur (FeS) clusters, reducing it to ubiquinol (CoQ 10 H 2 ) 68,69

doi: 10.1056/NEJMoa2212948 273 Van RooyI.Cakir-TasciogluS.HenninkW