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The anti-inflammatory effect is associated with the decreased expression of p65 and the increased phosphorylation of p65

Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway

Oncogene 36, 22552264 (2017)
Molecules like the cell cycle protein p21 have been reported to interact directly with GPX4, competitively or allosterically affecting its ubiquitination rate, thereby stabilizing GPX4 and enhancing cellular resistance under oxidative stress (Zheng et al., 2024)

Munoz-Elias, R
