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GSH in Cancer Dual Roles in Carcinogenesis and Drug Resistance (PubMed, 2019) Elevated Tumour GSH as a Driver of Chemotherapy Resistance A comprehensive review published on PubMed examined GSHs dual roles in cancer biology chemopreventive in normal cells through carcinogen detoxification by GST, and pathogenic in tumour cells where elevated GSH levels are associated with tumour progression and increased resistance to chemotherapeutic drugs and radiotherapy

[DOI] [PMC free article] [PubMed] [Google Scholar] 627.Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G

suggested that attempts to improve VO2 peak may reduce LFC and GGT levels [50]

Another strategy is to choose the best binding order of the different building blocks to minimize the formation of by-products under conditions that are not chemoselective for cereblon ligands

Targeting the IGF-1R in breast cancer: clinical evidence Both in vitro and in vivo evidence strongly suggest that the IGF-1 system could serve as a promising target candidate in BrCa therapeutics