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We first reported this when cultured hepatocytes were plated under low density (Lu and Ge 1992a

Manufacturers must consider these absorption characteristics when developing products, particularly those intended for systemic effects

Specific clinical scenarios where injections are the standard of care include pernicious anemia, severe malabsorption syndromes, post-bariatric surgery when oral supplementation has failed, and critically low serum B12 levels accompanied by neurological deterioration

Early care helps prevent long-term complications like post-concussion syndrome (PCS) and persistent headaches