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The R1 group of 16 was held tightly by two additional hydrogen bonds engaging the side chain of H64 from a neighboring protease protomer (C) and the backbone carbonyl of P168, in addition to a - interaction between the triazole ring of 16 and F305 of protomer B (Fig

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This is followed by normalizing histopathological changes in the kidney (Vasavan et al., 2020)