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The researchers highlighted silymarin's liver-protective effects in cases of drug-induced liver injury, fatty liver disease (both alcoholic and nonalcoholic), and alcoholic cirrhosis, attributing successes to the compound's ability to prevent cytotoxicity by reducing oxidative stress on the liver.3 Many of the studies covered in the review administered 420mg of silymarin per day

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Previous studies have reported inconsistent results when comparing oral, sublingual, and intramuscular administration, often limited by small sample sizes or heterogeneous populations (Vidal-Alaball et al., 2006