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GI events were the most common adverse effects, vast majority mild to moderate

Dosage of Oral Vitamin B12 Replacement Required In all the five studies, an oral (Delpres study via sublingual route) dose of 1000 g vitamin B12 was used with the exception of Kuzminskis study, whereby a higher dose of 2000 g was used

Those medications have undergone extensive testing and are regulated by the FDA
