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1-MNA and S-(5-adenosyl)-L-methionine (SAH) were obtained from Cayman Chemical Company (Ann Arbor, MI, USA)

Developed by Novo Nordisk, WEGOVY (semaglutide) is a GLP-1 receptor agonist designed to support sustainable weight loss when paired with a balanced diet and regular physical activity

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In its native structure, RNAase resists deamidation possibly because of the relatively rigid backbone in the loop stabilized by a disulfide between Cys-8 and Cys-12 and by the -turn at residues 6668, which could hinder the formation of the cyclic imide (52)