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A single B12 injection raises blood levels for 2 to 4 weeks, with noticeable energy and mood effects lasting 1 to 3 weeks

B12 shots, on the other hand, are simple injections of vitamin B12, a nutrient that supports several body functions
Chakrabarti, S., Guha, S., & Majumder, K
doi: 10.1007/s00221-008-1611-6