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However, in unhealthy physiological conditions, including diabetes or other metabolic abnormalities, a scarcity of substrates or cofactors for eNOS may produce superoxide instead of NO, a phenomenon referred to as uncoupling [68]

Kapila et al., 2016)

For example, direct GAPDH inhibitors 115 selectively kill highly glycolytic cancer cells, while an engineered lactate oxidase/catalase enzyme was shown to lower NADH levels and restore GAPDH activity, glycolytic ATP production, and proliferation in cells with impaired NAD regeneration 116

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elegans Glutathione S -transferases (GSTs) are a functionally diverse family of enzymes that utilize GSH in conjugation reactions [100]