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NRF2 activation reprograms defects in oxidative metabolism to restore macrophage function in chronic obstructive pulmonary disease [J

Loss of LKB1 kinase activity in Peutz-Jeghers Syndrome, and evidence for allelic and locus heterogeneity
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These design features yield a pharmacokinetic profile suitable for once-weekly administration, with a reported elimination half life of 78 days (DAscanio et al

After the behavioral study, the experimental animals were first anesthetized with ketamine (80 mg/kg) and xylazine (5 mg/kg) given intraperitoneally to ensure deep anesthesia and lack of pain perception
