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The mechanism of action of glyoxalase

Of particular interest, the ability of ferroptosis to target (chemo)therapy-resistant and metastatic cancers underscores its potential as a highly attractive strategy for future treatments [86-89]

In a model of amyotrophic lateral sclerosis (ALS) caused by C9orf72 gene mutations, the pathogenic poly-dipeptide GA50 directly binds to and inhibits SQOR, leading to excessive NLRP3 inflammasome activation in microglia and consequent mitochondrial dysfunction (Fu et al., 2023)

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Kirschen G.W., AlAshqar A., Miyashita-Ishiwata M., Reschke L., El Sabeh M., Borahay M.A

& Kveder, T