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Lack of physical activity (sedentary lifestyle), poor blood circulation , dehydration (drinking insufficient amount of water), stress, irritability, anxiety , and depression are also associated with the development of RLS

Its deficiency can lead to the development of anxiety disorders and depressive disorders

Busulfan induces oxidative stress- and Bcl-2 family gene-related apoptosis in epididymal sperm and testis of adult male mice Busulfan as a re-presentative chemotherapeutic agent

However, no significant effect was observed on the rates of heart failure or myocardial reinfarction (DiNicolantonio et al