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Development of a deletion mutant of Pseudomonas denitrificans that does not degrade 3hydroxypropionic acid

Studies have shown that high doses of PPR (e.g., 10 mg/kg) significantly reduce sperm motility, concentration, and viability in adult male rats, with adverse effects on key reproductive markers and antioxidant enzymes (70, 71)

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Topical calcineurin inhibitors, such as pimecrolimus and tacrolimus, can also be used in combination with topical corticosteroids (210)

Molinos M, Fiordalisi MF, Caldeira J, Almeida CR, Barbosa MA, Gonalves RM