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Those with digestive issues, like Crohns disease or celiac disease, that impair nutrient absorption

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

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Seshadri S, Destefano AL, Au R, Massaro JM, Beiser AS, Kelly-hayes M, Kase CS, Dagostino RB, Decarli C, Atwood LD, Wolf PA (2007) Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham study

Nature 508(7495):258-262