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In contrast, an overdose of APAP causes hepatotoxicity by saturating the sulfation pathway and generating NAPQI that leads to a robust reaction between NAPQI and hepatic glutathione stores, which subsequently depletes glutathione (Xie et al., 2015)
Wood JL and Graham A (1995)
In vitro responses were also observed for Fe(II) and Zn(II) with affinities of 400 and 93 nM, respectively [151]
