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The discovery of the existence of supercomplexes in the respiratory chain [114] and the recognition of their function [115] led to the modification of the fluid model to the plasticity model, which adds to the fluid model a new view of the structural and functional complexity in the transfer of electrons in the mitochondrial ETS, as well as the function of the CoQ 10 pool in the IMM [111,116,117]

In patients with CD, the expression of AMPssuch as -defensins (e.g., HD5, HD6), calprotectin (CRP), lactoferrin, lysozyme, elafin, galectin-1, galectin-3, cathelicidin, hepcidin, and lipocalinis frequently dysregulated (Gubatan et al., 2021)

As we age, the production of collagen decreases, leading to a loss of elasticity

294 Conversely, in hepatocytes, FUNDC1 silencing leads to the accumulation of dysfunctional mitochondria, release of mtDNA, overactivation of caspase-1, and excessive IL-1 production, thus promoting the initiation and progression of HCC