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Patients who receive bariatric surgery are at high risk of developing mental, cognitive, and neurological complications resulting from micronutrient deficiencies

58 Median time to the development of a full symptom complex of frequency, urgency, and pain was reported to be two years in one study

Moreover, many studies showed that metformin improves the expression of BDNF by increasing the histone acetylation along with the BDNF promoter, which was attributed to the activation of AMPK and CREB (Ameen et al., 2022

While your body produces it on its own, levels can decline with age

Its essential to be aware of these and seek medical attention if they occur