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The vast majority of the available evidence comes from small osseous defects seen in dental and maxillofacial surgery (Table 3)

Their stimulation produces both antinociceptive and anti-inflammatory effects, and evidence suggests functional cross-talk with the opioid system, resulting in enhanced analgesic efficacy [77,78]

doi: 10.1016/j.eclinm.2024.102789 [DOI] [PMC free article] [PubMed] [Google Scholar] 28.Lau DCW, Erichsen L, Francisco AM, Satylganova A, le Roux CW, McGowan B, Pedersen SD, Pietilinen KH, Rubino D, Batterham RL

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Rubes J, Selevan SG, Sram RJ et al (2007) GSTM1 genotype influences the susceptibility of men to sperm DNA damage associated with exposure to air pollution