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Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-1

18 This mechanism suggests that either substrate could firstly bind to NNMT independently

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Am J Psychiatry 2000;157:715-21

Ternary Complex Formation The developmental establishment of GH control over the IGF1 , IGFBP3 and IGFALS genes in early childhood initiates the dominance of the ternary complex formed by IGF-I or IGF-II and IGFBP-3 (or IGFBP-5) and ALS as the quantitatively most important circulating form of IGF-I and IGF-II (reviewed by Baxter (116)