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This common belief usually stems from an incorrect inference that B12 supplements have an appetite-stimulating effect

This includes: Using a sterile needle and syringe Inserting the needle at a 90-degree angle to the skin Aspirating to check for blood return before injecting Injecting slowly to minimize discomfort By following these steps, the Vitamin B12 goes into the muscle tissue effectively

Sub q should in theory give close to 100% bioavailability, but we really dont know the one PK study never tested it, so theres no measured number and no dosing conversion behind it

While oral supplements can be helpful, they have to pass through your entire digestive system, where absorption can be unpredictable

It also helps to define what success looks like for you with your provider, since goals differ from person to person