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Study protocol for SFX-01 after subarachnoid haemorrhage (SAS): a multicentre randomised double-blinded, placebo controlled trial

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For example, in macrophages, the activation of NF-B in response to LPS stimulation leads to the production of proinflammatory cytokines e.g., TNF- and interleukin-6 (IL-6), which are important for the initiation and regulation of the immune response [130]

TF protected iRPE cells from sustained iron overload, which mimics GA features Iron accumulation is observed in the retina of AMD patients, and our clinical results suggest that an iron-TF imbalance favors iron overload toxic situation in GA eyes, which still have progression threat