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Therefore, investigating different factors and signaling pathways involved in the alteration of extracellular matrix (ECM) turnover, and the subsequent catabolic damage to cartilage holds chief importance in understanding OA development

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GHK-Cu is a bioactive peptide, a tripeptide complex containing glycine-histidine-lysine bound to copper (Cu), hence its other name - "copper peptide," due to the presence of copper in its composition