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Hypoxia, activation of inflammatory cells, disturbance in coagulation, and release of toxic mediators are main factors that lead to failure of multiple organs

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These help neutralise free radicals from unhealthy factors such as UV sun exposure, smoking, pollution, and environmental stressors contributing to early skin ageing

A key mechanism contributing to MDR involves the energy-dependent efflux of drugs from cancer cells, leading to decreased intracellular drug concentrations and reduced efficacy