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Evidence from germ-free mouse models demonstrates an essential role for the microbiota in ENS maturation and function, with the absence of commensal colonization leading to reduced enteric neuronal density, impaired intestinal peristaltic reflexes (106108), and defective recruitment of EGCs into the intestinal mucosa during development, ultimately compromising neuroimmune integration and homeostatic regulation (109)

They have fewer side effects and can be delivered easily to various parts of the body

doi: 10.1007/s11894-015-0473-x

[DOI] [PubMed] [Google Scholar] 99.Busch K., Glish G., Mcluckey S

Summary: Cagrilintide and retatrutide are investigational injectable medicines being studied for obesity and type 2 diabetes in men, targeting multiple hormonal pathways to reduce appetite, improve blood glucose control, and increase energy expenditure, but neither is currently licensed in the UK