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LDE has been frequently associated with gold, antimalarials, antihypertensives, NSAIDs, proton-pump inhibitors, anti-diabetics, anti-tuberculars, TNF- inhibitors, tyrosine kinase inhibitors, checkpoint inhibitors, and biological agents.[6,7,8] Although the mechanism of LDE is not fully understood, it has been hypothesized that cross-reactivity between the drug and keratinocytes both acting as antigens, leading to T cell-mediated autoimmune damage of basal keratinocytes

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Urr diteur: ERPI Parution 2012

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More advanced melanomas (Stage III or IV) may require a combination of treatments, including surgery, drug therapy, and radiation therapy