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The immune response is the process most markedly affected by the drug

doi: 10.1016/j.pain.2011.09.014

The combination therapy of SAHA (40 mg/kg, intraperitoneal injection every 3 days) and B7x neutralizing antibody (200 g/mouse, intraperitoneal injection every 2 days) significantly delayed tumor growth, with a tumor inhibition rate of 80.6%, and significantly increased the infiltration of CD8 + and CD4 + T cells in the tumor microenvironment (67)

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