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Jan 2014;101(1):e90-99

More serious but rare side effects include increased blood pressure, heart palpitations, dizziness, restlessness, tremors, insomnia, shortness of breath, chest pain, severe skin reactions, and swelling in the legs and ankles

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Clinical trials demonstrated that participants on the highest dose of tirzepatide (15 mg weekly) lost an average of 22.5% of their body weight over 72 weeks
