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S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

Cellular damage in DILI can reflect toxic effects of the culprit medication or its metabolites, or immune-mediated effects (Figure 1)

Mild cases respond well to elevating the head during sleep (15-30 cm), avoiding meals two to three hours before bedtime, steering clear of strong gastric stimulants (coffee, alcohol), problematic foods (fatty items, chocolate), and quitting smoking

Some patients experience fluid retention, particularly early in the protocol

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