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PubMed, Pizzorno, Joseph
TGF- Wnt/B-catenin, Notch, and connective tissue growth factor (CTGF) pathways induce the expression of transcription factors Snail, Slug, Twist, and ZEB1 (108110)
Enteroviral 2B protein has been shown to interact with mitochondrial voltage-dependent anion channel 3 (VDAC3) to induce ROS production, and knockdown of VDAC3 significantly reduces EV71-induced mtROS generation and viral replication 132
In addition, research has shown that ROS produced in the mitochondria during T-cell activation affects Ca 2+ homeostasis in a concentration-dependent manner, activating the TF NFAT (107, 131)
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