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In clinical use, significant side effects are uncommon, and the vast majority of patients tolerate the therapy without problems
Gastric mucosal healing involves direct stimulation of angiogenesis via VEGF upregulation, rebuilding the submucosal capillary network that underlies epithelial integrity

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Tirzepatide does not typically disrupt sleep, though some researchers report tirzepatide-related sleep changes that may need management

doi: 10.1111/j.1471-4159.2010.07109.x
