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Corroborating these findings, Yang et al (58) demonstrated that lactate-induced alterations in SCD1/ACSL4 expression and ferroptosis resistance are correlated with lactate production levels in esophageal squamous cell carcinoma (ESCC)
Glutathione is a master antioxidant naturally produced by the body
These effects were associated with the inhibition of NF-B nuclear translocation and reduced phosphorylation of B and mitogen-activated protein kinases, including p38, extracellular signal-regulated kinases 1 and 2 (Erk 1/2), and c-Jun N-terminal kinase (282)
BMJ 388:e080952
doi: 10.1016/j.cell.2020.02.058
