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6.1 Therapeutic approaches targeting circadian rhythms in kidney and eye diseases Circadian rhythm disruption plays a critical role in the pathogenesis of kidney and ocular diseases by promoting inflammation, oxidative stress, fibrosis, and hormonal imbalance

Indeed, tumor cells in the hypoxic microenvironment have elevated demands for glycolysis, in turn, leading to increased lactic acid and acidosis

Ferreira et al., 2013)

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There was a significant decrease in these parameters during fasting in the CT group