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Compounding pharmacies have begun creating formulations that combine tirzepatide with vitamin B12 (cyanocobalamin or methylcobalamin), though these are not FDA-approved combinations

That triple mechanism is what produced the headline-grabbing results from the Phase 2 NEJM trial, where the 12 mg dose group achieved an average 24.2% body weight reduction over 48 weeks

therefore, the results should be interpreted with caution

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If you're still unsure, the best way to decide which method is right for you is to talk to your doctor